Two-year neonatal outcome following PPROM prior to 25 weeks with a prolonged period of oligohydramnios.

Improved neonatal survival data have been reported following early preterm prelabour rupture of membranes (PPROM) prior to 25 weeks gestation with a prolonged latency to delivery and persistent oligohydramnios. However, data regarding long-term respiratory and neurological morbidity are lacking. To evaluate the respiratory and neurological outcome data at two years of age in a cohort of infants born following PPROM prior to 25 weeks with a prolonged latency (14 days) to delivery and compare the data to an aged matched group of infants. Retrospective case note analysis over a 43-month period at Saint Luc University Hospital, Brussels. 15 surviving infants born following PPROM were matched to a group of 30 control infants. Although there was no significant difference in the incidence of BPD between the groups (33% vs 27%, p=0.24), the length of hospitalisation, duration of respiratory support and number of hospital readmissions for respiratory indications were all significantly higher for infants born following a prolonged period of oligohydramnios. There were no major anomalies on cranial ultrasound in the PPROM group and Baileys developmental assessment at 20-24 months corrected gestational age showed no difference between the two groups (Mental development index 93.9 vs 94.4 and Psychomotor development index 95.5 vs 95.8 respectively p = ns). Neurodevelopmental outcome appears encouraging in this cohort although these infants are at high risk of prolonged initial hospitalisation and significant respiratory morbidity in the first two-years of life. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Citation

O Williams, B Michel, G Hutchings, C Debauche, C Hubinont. Two-year neonatal outcome following PPROM prior to 25 weeks with a prolonged period of oligohydramnios. Early human development. 2012 Aug;88(8):657-61

Mesh Tags

PMID: 22682720

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