RNA in centrosomes: structure and possible functions.

Konstantin Chichinadze, Ann Lazarashvili, Jaba Tkemaladze

Protoplasma 2013 Feb

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A novel RNA was detected in the centrosomes of Spisula solidissima mollusk oocytes in 2006. This RNA was named centrosomal RNA (cnRNA); five different cnRNAs were described. During the sequencing of the first transcript, cnRNA 11, it was discovered that the transcript contained a conserved structure--a reverse transcriptase domain. In a 2005 study, we speculated about several possible mechanisms for determining the most important functions of centrosomal structures and referred to one of them as an "RNA-dependent mechanism". The discovery of RNA specific to the centrosome is indirect evidence of the centrosomal hypothesis of cellular aging and differentiation. The presence of a reverse transcriptase domain in this type of RNA, together with its uniqueness and specificity, makes the centrosome a place of information storage and reproduction.

Citation

Konstantin Chichinadze, Ann Lazarashvili, Jaba Tkemaladze. RNA in centrosomes: structure and possible functions. Protoplasma. 2013 Feb;250(1):397-405