Nikè V J A Büller, Sanne L Rosekrans, Jessica Westerlund, Gijs R van den Brink
Department of Gastroenterology & Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands.
Physiology (Bethesda, Md.) 2012 JunHomeostasis of the rapidly renewing intestinal epithelium depends on a balance between cell proliferation and loss. Indian hedgehog (Ihh) acts as a negative feedback signal in this dynamic equilibrium. We discuss recent evidence that Ihh may be one of the key epithelial signals that indicates epithelial integrity to the underlying mesenchyme.
Nikè V J A Büller, Sanne L Rosekrans, Jessica Westerlund, Gijs R van den Brink. Hedgehog signaling and maintenance of homeostasis in the intestinal epithelium. Physiology (Bethesda, Md.). 2012 Jun;27(3):148-55
PMID: 22689790
View Full Text