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Homeostasis of the rapidly renewing intestinal epithelium depends on a balance between cell proliferation and loss. Indian hedgehog (Ihh) acts as a negative feedback signal in this dynamic equilibrium. We discuss recent evidence that Ihh may be one of the key epithelial signals that indicates epithelial integrity to the underlying mesenchyme.

Citation

Nikè V J A Büller, Sanne L Rosekrans, Jessica Westerlund, Gijs R van den Brink. Hedgehog signaling and maintenance of homeostasis in the intestinal epithelium. Physiology (Bethesda, Md.). 2012 Jun;27(3):148-55

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PMID: 22689790

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