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The unprecedented polymorphism of the non-steroidal anti-inflammatory drug (NSAID) flufenamic acid (FFA) is described here. Nine polymorphs were accessed through the use of polymer-induced heteronucleation (PIHn) and solid-solid transformation at low temperature. Structural elucidation of six of these forms, in addition to the two previously known forms, makes FFA indisputably octamorphic. Although the structure of at least one other form of FFA remains elusive, the occurrence of most of these polymorphs under one crystallization condition through PIHn illustrates that a fine interplay exists among the kinetic factors that lead to phase selection in this NSAID.


Vilmalí López-Mejías, Jeff W Kampf, Adam J Matzger. Nonamorphism in flufenamic acid and a new record for a polymorphic compound with solved structures. Journal of the American Chemical Society. 2012 Jun 20;134(24):9872-5

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PMID: 22690822

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