Liver dysfunction in patients with early syphilis: a retrospective study.

Eisuke Adachi, Tomohiko Koibuchi, Michio Okame, Hidenori Sato, Tadashi Kikuchi, Michiko Koga, Hitomi Nakamura, Aikichi Iwamoto, Takeshi Fujii

Department of Infectious Diseases and Applied Immunology, Research Hospital of the Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2013 Feb

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Syphilis is one of the unrecognized etiologies of liver dysfunction. The incidence of syphilitic hepatitis is currently unknown. We conducted a retrospective study of causative agents of liver dysfunction at the time of diagnosis of early syphilis. Our study shows that 39 % (44/112) of early syphilis patients have live r enzyme abnormalities at the time of diagnosis and that 2.7 % (3/112) of patients are diagnosed with syphilitic hepatitis. Clinicians should include syphilitic hepatitis in the differential diagnosis for those patients with sexually transmitted diseases presenting with liver enzyme abnormalities.

Citation

Eisuke Adachi, Tomohiko Koibuchi, Michio Okame, Hidenori Sato, Tadashi Kikuchi, Michiko Koga, Hitomi Nakamura, Aikichi Iwamoto, Takeshi Fujii. Liver dysfunction in patients with early syphilis: a retrospective study. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2013 Feb;19(1):180-2