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Two different series of naphthalene and anthracene based hydroxamic acids having amino acid derivatives were synthesized. Single strand DNA cleavage was achieved on irradiation of newly synthesized hydroxamic acids by UV light (≥350nm). Both reactive oxygen species (ROS) and generated radicals from hydroxamic acids were shown to be responsible for the DNA cleavage. Further, DNA cleaving ability of hydroxamic acids was found to be dependent on its concentration and on its structure. Copyright © 2012 Elsevier Ltd. All rights reserved.


Nilanjana Chowdhury, Swagata Dasgupta, N D Pradeep Singh. Photoinduced DNA cleavage by anthracene based hydroxamic acids. Bioorganic & medicinal chemistry letters. 2012 Jul 15;22(14):4668-71

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PMID: 22704891

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