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Implantable electrodes interface with the human body for a range of therapeutic as well as diagnostic applications. Here we provide an overview of controlled delivery strategies used in neuro-bionics. Controlled delivery of bioactive molecules has been used to minimise reactive cellular and tissue responses and/or promote nerve preservation and neurite outgrowth toward the implanted electrode. These effects are integral to establishing a chronically stable and effective electrode-neural communication. Drug-eluting bioactive coatings, organic conductive polymers, or integrated microfabricated drug delivery channels are strategies commonly used. Copyright © 2012 Elsevier B.V. All rights reserved.


Zhilian Yue, Simon E Moulton, Mark Cook, Stephen O'Leary, Gordon G Wallace. Controlled delivery for neuro-bionic devices. Advanced drug delivery reviews. 2013 Apr;65(4):559-69

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PMID: 22705546

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