Controlled delivery for neuro-bionic devices.

Zhilian Yue, Simon E Moulton, Mark Cook, Stephen O'Leary, Gordon G Wallace

ARC Centre of Excellence for Electromaterials Science (ACES), Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong, NSW 2522, Australia.

Advanced drug delivery reviews 2013 Apr

filter terms:

Implantable electrodes interface with the human body for a range of therapeutic as well as diagnostic applications. Here we provide an overview of controlled delivery strategies used in neuro-bionics. Controlled delivery of bioactive molecules has been used to minimise reactive cellular and tissue responses and/or promote nerve preservation and neurite outgrowth toward the implanted electrode. These effects are integral to establishing a chronically stable and effective electrode-neural communication. Drug-eluting bioactive coatings, organic conductive polymers, or integrated microfabricated drug delivery channels are strategies commonly used. Copyright © 2012 Elsevier B.V. All rights reserved.

Citation

Zhilian Yue, Simon E Moulton, Mark Cook, Stephen O'Leary, Gordon G Wallace. Controlled delivery for neuro-bionic devices. Advanced drug delivery reviews. 2013 Apr;65(4):559-69