Stereoselective synthesis of P-chirogenic dibenzophosphole-boranes via aryne intermediates.

Vincent Diemer, Anaïs Berthelot, Jérôme Bayardon, Sylvain Jugé, Frédéric R Leroux, Françoise Colobert

Laboratoire de Chimie Moléculaire (UMR CNRS 7509), Université de Strasbourg, ECPM, 25 rue Becquerel, 67087 Strasbourg, France.

The Journal of organic chemistry 2012 Jul 20

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A new aryne-mediated tandem cross-coupling/P-cyclization sequence starting from tertiary phosphine-boranes and 1,2-dibromobenzenes is reported. P-chirogenic dibenzophospholes become accessible in a regio-, chemo-, and diastereoselective way.

Citation

Vincent Diemer, Anaïs Berthelot, Jérôme Bayardon, Sylvain Jugé, Frédéric R Leroux, Françoise Colobert. Stereoselective synthesis of P-chirogenic dibenzophosphole-boranes via aryne intermediates. The Journal of organic chemistry. 2012 Jul 20;77(14):6117-27