Regulation of TGF-β signal transduction by mono- and deubiquitylation of Smads.

Polyubiquitylation leading to proteasomal degradation is a well-established mechanism for regulating TGF-β signal transduction components such as receptors and Smads. Recently, an equally important role was suggested for monoubiquitylation of both Smad4 and receptor-associated Smads that regulates their function without protein degradation. Monoubiquitylation of Smads was discovered following the identification of deubiquitylases required for TGF-β signaling, suggesting that continuous cycles of Smad mono- and deubiquitylation are required for proper TGF-β signal transduction. Here we summarize and discuss recent work on Smad mono- and deubiquitylation. Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Sirio Dupont, Masafumi Inui, Stuart J Newfeld. Regulation of TGF-β signal transduction by mono- and deubiquitylation of Smads. FEBS letters. 2012 Jul 04;586(14):1913-20

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PMID: 22710170

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