Characterization of an unusual ring-contraction degradant of the antifungal agent posaconazole.

Wenqing Feng, Bruce D Hilton, Wendy Zhong, Jiong Yang, Xi Yang, Weidong Tong, Gary E Martin

Magnetic resonance in chemistry : MRC 2012 Aug

filter terms:

Posaconazole, a clinically useful antifungal agent, has several known oxidative degradation products involving the piperazine ring near the center of the molecule. A novel degradant was recently isolated and characterized spectroscopically as a novel ring-contraction product incorporating a dihydroimidazolium moiety in lieu of the normally present piperazine ring. Copyright © 2012 John Wiley & Sons, Ltd.

Citation

Wenqing Feng, Bruce D Hilton, Wendy Zhong, Jiong Yang, Xi Yang, Weidong Tong, Gary E Martin. Characterization of an unusual ring-contraction degradant of the antifungal agent posaconazole. Magnetic resonance in chemistry : MRC. 2012 Aug;50(8):576-9