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In 2006, panitumumab, the first fully human antibody generated from transgenic mice, was approved for clinical use by the US Food and Drug Administration (FDA). Since then, a further seven such antibodies have been approved. In this chapter, we discuss how transgenic mice technologies can provide a powerful platform for creating human therapeutic antibodies.


E-Chiang Lee, Michael Owen. The application of transgenic mice for therapeutic antibody discovery. Methods in molecular biology (Clifton, N.J.). 2012;901:137-48

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PMID: 22723098

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