Droplet microfluidics based microseparation systems.

Lab on a chip (LOC) technology is a promising miniaturization approach. The feature that it significantly reduced sample consumption makes great sense in analytical and bioanalytical chemistry. Since the start of LOC technology, much attention has been focused on continuous flow microfluidic systems. At the turn of the century, droplet microfluidics, which was also termed segmented flow microfluidics, was introduced. Droplet microfluidics employs two immiscible phases to form discrete droplets, which are ideal vessels with confined volume, restricted dispersion, limited cross-contamination, and high surface area. Due to these unique features, droplet microfluidics proves to be a versatile tool in microscale sample handling. This article reviews the utility of droplet microfluidics in microanalytical systems with an emphasize on separation science, including sample encapsulation at ultra-small volume, compartmentalization of separation bands, isolation of droplet contents, and related detection techniques. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Zhiliang Xiao, Menglei Niu, Bo Zhang. Droplet microfluidics based microseparation systems. Journal of separation science. 2012 Jun;35(10-11):1284-93

Mesh Tags

Substances

PMID: 22733508

search → result