Kinetic resolution of secondary alcohols by the combination of a chiral Brønsted acid, DABCO, and acetyl chloride.
Hiroki Mandai, Kyouta Murota, Koichi Mitsudo, Seiji Suga
Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan. mandai@cc.okayama-u.ac.jp
Organic letters 2012 Jul 6An efficient and simple protocol for the kinetic resolution of secondary alcohols is presented. The new system is based on a combination of chiral Brønsted acid, DABCO, and acetyl chloride and gives various enantioenriched alcohols with selectivity factors up to 105.
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Hiroki Mandai, Kyouta Murota, Koichi Mitsudo, Seiji Suga. Kinetic resolution of secondary alcohols by the combination of a chiral Brønsted acid, DABCO, and acetyl chloride. Organic letters. 2012 Jul 6;14(13):3486-9
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PMID: 22734845
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