Application of ADME process in vivo in combination with network pharmacology in study of traditional Chinese medicine].

Haiyu Xu, Luqi Huang, Peng Lu, Hongjun Yang

Institute of Chinese Material Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. hy_xu627@163.com

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 2012 Jan

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Application of network pharmacology in traditional Chinese medicine (TCM) will be benefit for clarifying active components and mechanism of action of TCM and increase the study level of new drug of Chinese medicine. ADME process can identify drug components from TCM and obtain the possible metabolites which can clarify active components in vivo. For the complexity of active constituents of TCM, it indicated that the ADME process will be the precondition for application of network pharmacology in TCM. This paper introduced the study ideas of the combination of ADME process in vivo and network pharmacology.

Citation

Haiyu Xu, Luqi Huang, Peng Lu, Hongjun Yang. Application of ADME process in vivo in combination with network pharmacology in study of traditional Chinese medicine]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Jan;37(2):142-5