Selective inhibition of inducible nitric oxide synthase by derivatives of acetamidine.

Cristina Maccallini, Antonia Patruno, Alessandra Ammazzalorso, Barbara De Filippis, Marialuigia Fantacuzzi, Sara Franceschelli, Letizia Giampietro, Simona Masella, Maria Luisa Tricca, Rosa Amoroso

Dipartimento di Scienze del Farmaco, Università G. d'Annunzio, Chieti, Italy.

Medicinal chemistry (Shāriqah (United Arab Emirates)) 2012 Nov

filter terms:

A new series of phenyl- and heteryl acetamidines were synthesized and evaluated as inhibitors of nitric oxide synthases (NOS). While the N-substitution of the acetamidine moiety with different heterocycles appears to completely destroy the activity, linking the phenyl core preserves it. Moreover, it was observed a strong dependence of the phenylacetamidines potency of action from the length of the alkyl chain that connects the aromatic ring to the acetamidine moiety.

Citation

Cristina Maccallini, Antonia Patruno, Alessandra Ammazzalorso, Barbara De Filippis, Marialuigia Fantacuzzi, Sara Franceschelli, Letizia Giampietro, Simona Masella, Maria Luisa Tricca, Rosa Amoroso. Selective inhibition of inducible nitric oxide synthase by derivatives of acetamidine. Medicinal chemistry (Shāriqah (United Arab Emirates)). 2012 Nov;8(6):991-5