Myelin basic protein synthesis is regulated by small non-coding RNA 715.

Nina M Bauer, Christina Moos, Jack van Horssen, Maarten Witte, Paul van der Valk, Benjamin Altenhein, Heiko J Luhmann, Robin White

EMBO reports 2012 Sep

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Oligodendroglial Myelin Basic Protein (MBP) synthesis is essential for myelin formation in the central nervous system. During oligodendrocyte differentiation, MBP mRNA is kept in a translationally silenced state while intracellularly transported, until neuron-derived signals initiate localized MBP translation. Here we identify the small non-coding RNA 715 (sncRNA715) as an inhibitor of MBP translation. SncRNA715 localizes to cytoplasmic granular structures and associates with MBP mRNA transport granule components. We also detect increased levels of sncRNA715 in demyelinated chronic human multiple sclerosis lesions, which contain MBP mRNA but lack MBP protein.

Citation

Nina M Bauer, Christina Moos, Jack van Horssen, Maarten Witte, Paul van der Valk, Benjamin Altenhein, Heiko J Luhmann, Robin White. Myelin basic protein synthesis is regulated by small non-coding RNA 715. EMBO reports. 2012 Sep;13(9):827-34