Synthesis and antitumor activity of novel quinazoline derivatives containing thiosemicarbazide moiety.

Junbo He, Xiaoguo Wang, Xiaoqin Zhao, Yongju Liang, Hongwu He, Liwu Fu

Key Laboratory of Pesiticide & Chemistry Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, PR China.

European journal of medicinal chemistry 2012 Aug

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Series of novel derivatives of quinazoline containing thiosemicarbazide moiety 5 and 9 have been synthesized and tested for their antitumor activities in vitro against a panel of five human cancer cell lines. Bioassay results indicated that most of the prepared compounds exhibited cytotoxicity against various cancer cells. From the structure-activity relationships it was found that unsubstituted quinazoline ring and benzene ring or halogen substituted benzene ring in quinazoline derivatives 5 and 9 would be the most favorable for their antitumor activity. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

Citation

Junbo He, Xiaoguo Wang, Xiaoqin Zhao, Yongju Liang, Hongwu He, Liwu Fu. Synthesis and antitumor activity of novel quinazoline derivatives containing thiosemicarbazide moiety. European journal of medicinal chemistry. 2012 Aug;54:925-30