Regulation of GPCR-mediated smooth muscle contraction: implications for asthma and pulmonary hypertension.

D B Wright, S Tripathi, A Sikarwar, K T Santosh, J Perez-Zoghbi, O O Ojo, N Irechukwu, J P T Ward, D Schaafsma

Department of Asthma, Allergy, and Lung Biology, King's College, London, United Kingdom.

Pulmonary pharmacology & therapeutics 2013 Feb

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Contractile G-protein-coupled receptors (GPCRs) have emerged as key regulators of smooth muscle contraction, both under healthy and diseased conditions. This brief review will discuss some key topics and novel insights regarding GPCR-mediated airway and vascular smooth muscle contraction as discussed at the 7th International Young Investigators' Symposium on Smooth Muscle (2011, Winnipeg, Manitoba, Canada) and will in particular focus on processes driving Ca(2+)-mobilization and -sensitization. Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

D B Wright, S Tripathi, A Sikarwar, K T Santosh, J Perez-Zoghbi, O O Ojo, N Irechukwu, J P T Ward, D Schaafsma. Regulation of GPCR-mediated smooth muscle contraction: implications for asthma and pulmonary hypertension. Pulmonary pharmacology & therapeutics. 2013 Feb;26(1):121-31