Amadori-glycated phosphatidylethanolamine up-regulates telomerase activity in PANC-1 human pancreatic carcinoma cells.

Takahiro Eitsuka, Kiyotaka Nakagawa, Yuichi Ono, Naoto Tatewaki, Hiroshi Nishida, Tadao Kurata, Naoki Shoji, Teruo Miyazawa

Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata 956-8603, Japan. eitsuka@nupals.ac.jp

FEBS letters 2012 Jul 30

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Several lines of experimental data have highlighted a key role of Amadori-glycated phosphatidylethanolamine (Amadori-PE) in the development of diabetic complications. Recent epidemiological studies suggest that diabetes mellitus could be a risk factor for some cancers. A characteristic of cancer cells is their immortal phenotype, and the enzyme telomerase contributes to the infinite replicative potential of cancer cells. The purpose of this study was to obtain new information about the effect of Amadori-PE on the regulation of telomerase in PANC-1 human pancreatic carcinoma cells. Amadori-PE enhanced cellular telomerase in a time- and dose-dependent manner by up-regulating hTERT expression through induction of c-myc. These results provide experimental evidence for a novel role of Amadori-PE in linking diabetes and cancer. Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Citation

Takahiro Eitsuka, Kiyotaka Nakagawa, Yuichi Ono, Naoto Tatewaki, Hiroshi Nishida, Tadao Kurata, Naoki Shoji, Teruo Miyazawa. Amadori-glycated phosphatidylethanolamine up-regulates telomerase activity in PANC-1 human pancreatic carcinoma cells. FEBS letters. 2012 Jul 30;586(16):2542-7