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Dilated cardiomyopathy (DCM) is a highly prevalent and often lethal disease in Irish wolfhounds. Complex segregation analysis indicated different loci involved in pathogenesis. Linear fixed and mixed models were used for the genome-wide association study. Using 106 DCM cases and 84 controls we identified one SNP significantly associated with DCM on CFA37 and five SNPs suggestively associated with DCM on CFA1, 10, 15, 21 and 17. On CFA37 MOGAT1 and ACSL3 two enzymes of the lipid metabolism were located near the identified SNP.


Ute Philipp, Andrea Vollmar, Jens Häggström, Anne Thomas, Ottmar Distl. Multiple Loci are associated with dilated cardiomyopathy in Irish wolfhounds. PloS one. 2012;7(6):e36691

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PMID: 22761652

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