Bingzhen Zhang, Bingqin Dai, Xingliang Zhang, Zhiping Wang
Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, China.
Gene 2012 Oct 1To evaluate the association between vascular endothelial growth factor (VEGF) gene polymorphisms and the risk of recurrent spontaneous abortion (RSA), a meta-analysis of published case-control studies for the VEGF gene polymorphisms (gene polymorphisms reported more than three times were selected) and the risk of RSA. Odds ratios (ORs) and 95% confidence intervals (CIs) for codominant, dominant and recessive genetic models were assessed by RevMan software. Eight studies with 2813 cases and 2830 controls were included in this meta-analysis. The pooled analysis showed that -2578C/A, -1154G/A polymorphisms of VEGF were not significantly associated with the risk of RSA neither under codominant model nor under dominant model, nor under recessive model. Whereas, for -634G/C polymorphism, the pooled OR and 95% CI were 1.23 (1.01-1.49) under recessive model; and for 936C/T polymorphism, the pooled OR and 95% CI were 1.34 (1.07-1.67) and 1.40 (1.09-1.80) under codominant and dominant models, respectively. This meta-analysis suggested that VEGF gene -2578C/A, -1154G/A polymorphisms were not significantly associated with the risk of RSA, whereas, -634G/C and +936C/T polymorphisms were associated with the risk of RSA under specific genetic models. Copyright © 2012 Elsevier B.V. All rights reserved.
Bingzhen Zhang, Bingqin Dai, Xingliang Zhang, Zhiping Wang. Vascular endothelial growth factor and recurrent spontaneous abortion: a meta-analysis. Gene. 2012 Oct 1;507(1):1-8
PMID: 22766401
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