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To study the association of maternal prepregnancy body mass index (BMI) with serum concentrations of hCG in early pregnancy. Cross-sectional study. Oslo University Hospital, Norway, 1996-2010. Among 3,301 pregnancies with live-born offspring conceived after assisted reproductive techniques, 2,611 women had information on serum hCG concentrations on day 16 after ovulation induction and prepregnancy BMI: 2,110 mothers with singleton and 501 mothers with multiple pregnancy. None. Human chorionic gonadotropin concentration. Geometric mean hCG concentration was higher in multiple pregnancies (190 IU/L) than in singleton pregnancies (106 IU/L). In singleton pregnancies geometric mean serum concentration decreased from 117 IU/L in women with BMI <20 kg/m(2) to 86 IU/L in women with BMI ≥ 35 kg/m(2). In multiple pregnancies, the corresponding decrease was from 226 IU/L to 130 IU/L. There was a significant negative association of BMI with hCG concentrations log transformed in the study sample as a whole (regression coefficient -0.013), in singleton pregnancies (regression coefficient -0.012), and in multiple pregnancies (regression coefficient -0.03). Serum hCG concentrations were negatively associated with maternal prepregnancy BMI. One possible explanation may be an effect of adipose tissue-derived signaling molecules on hCG secretion by the implanting embryo. Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.


Anne Eskild, Peter Fedorcsak, Lars Mørkrid, Tom G Tanbo. Maternal body mass index and serum concentrations of human chorionic gonadotropin in very early pregnancy. Fertility and sterility. 2012 Oct;98(4):905-10

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PMID: 22769733

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