Synthesis and fungicidal activity of novel 2,3-disubstituted-1,3-benzoxazines.

Zilong Tang, Zhonghua Zhu, Zanwen Xia, Hanwen Liu, Jinwen Chen, Wenjing Xiao, Xiaoming Ou

Molecules (Basel, Switzerland) 2012 Jul 06

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A series of new 2,3-disubstituted-3,4-dihydro-2H-1,3-benzoxazines were prepared in moderate to excellent yields by aza-acetalizations of aromatic aldehydes with 2-(N-substituted aminomethyl)phenols in the presence of TMSCl. Their structures were confirmed by IR, ¹H-NMR, ¹³C-NMR, MS and elemental analysis. The fungicidal activities of the target compounds were preliminarily evaluated, and some compounds exhibited good activity against Rhizoctonia solani.

Citation

Zilong Tang, Zhonghua Zhu, Zanwen Xia, Hanwen Liu, Jinwen Chen, Wenjing Xiao, Xiaoming Ou. Synthesis and fungicidal activity of novel 2,3-disubstituted-1,3-benzoxazines. Molecules (Basel, Switzerland). 2012 Jul 06;17(7):8174-85