Novel thiol- and thioether-containing amino acids: cystathionine and homocysteine families.

Luigi Longobardo, Nunzia Cecere, Marina DellaGreca, Ivan de Paola

Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, Via Cinthia 4, 80126 Naples, Italy. luilongo@unina.it

Amino acids 2013 Feb

filter terms:

Natural L-homocysteine and L,L-cystathionine, along with a series of unnatural analogues, have been prepared from L-aspartic and L-glutamic acid. Manipulation of the protected derivatives provided ω-iodoamino acids, which were used in thioalkylation reactions of sulfur nucleophiles, such as the ester of L-cysteine and potassium thioacetate.

Citation

Luigi Longobardo, Nunzia Cecere, Marina DellaGreca, Ivan de Paola. Novel thiol- and thioether-containing amino acids: cystathionine and homocysteine families. Amino acids. 2013 Feb;44(2):443-8