Non-classical congenital adrenal hyperplasia in association with porphyria cutanea tarda: co-incidence or trigger?

We present an interesting case of porphria cutanea tarda with hereditary haemochromatosis and non-classical congenital adrenal hyperplasia in a postmenopausal woman. This unusual combination of conditions does not appear to be reported in the literature. The exact mechanism causing porphyria in this patient is not clear. We consider the possibility that in addition to iron accumulation and excess alcohol, altered steroid milieu may have been a possible trigger for the development of bullous lesions in this patient.

Citation

Mamatha Ramaswamy, Russell Ead, Helen Buckler, John Houghton, Mary Felicity Stewart. Non-classical congenital adrenal hyperplasia in association with porphyria cutanea tarda: co-incidence or trigger? Annals of clinical biochemistry. 2012 Sep;49(Pt 5):500-2

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PMID: 22783026

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