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To report a case of amantadine induced corneal edema in a pediatric patient. A comprehensive ophthalmologic evaluation was performed to a 16-year-old female patient who presented with bilateral, painless loss of vision and corneal edema. Review of the patient's medical information revealed the use of amantadine to alleviate extrapyramidal side effects secondary to psychiatric medications. Complete resolution of bilateral corneal edema was achieved one month after cessation of amantadine therapy. Amantadine induced corneal edema should be considered in the differential diagnosis of bilateral corneal edema in all age groups. Review of the toxic side effects of systemic medications should be performed in every patient who presents with bilateral corneal edema.


Luis A Santiago-Cabán, Enrique Rivera, Vanessa López-Beauchamp. Bilateral corneal edema secondary to amantadine in the pediatric population: a case report. Boletín de la Asociación Médica de Puerto Rico. 2012 Jan-Mar;104(1):69-76

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PMID: 22788084

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