Increasing effect of an oral intake of L-hydroxyproline on the soluble collagen content of skin and collagen fragments in rat serum.

We examined the effects of oral L-hydroxyproline (Hyp) on collagen in the body. After 2 weeks' administration of Hyp (0.5 or 1 g/kg) to F344 male rats, the soluble collagen content of the skin had increased, and the serum concentration of collagen peptides was correlated with the skin content of soluble collagen. This result suggests that oral Hyp augmented collagen metabolism.

Citation

Mami Aoki, Kouzou Suto, Miho Komatsu, Ayako Kamimura, Koji Morishita, Motoo Yamasaki, Toshifumi Takao. Increasing effect of an oral intake of L-hydroxyproline on the soluble collagen content of skin and collagen fragments in rat serum. Bioscience, biotechnology, and biochemistry. 2012;76(6):1242-4

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PMID: 22790956

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