Establishment of a monitoring system to detect inhibition of mRNA processing.

Ken-ichi Fujita, Masumi Okamura, Sachiko Nishimoto, Tomoya Kurihara, Keiko Momma, Yusaku Miyamae, Taiho Kambe, Masaya Nagao, Hiroshi Narita, Seiji Masuda

Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.

Bioscience, biotechnology, and biochemistry 2012

filter terms:

A number of proteins complete mRNA processing in the nucleus, thus, inhibitor of mRNA processing is worth finding to analyze the mechanism of mRNA maturation in detail. Here, we established a monitoring system for mRNA processing using a test compound, spliceostatin A (SSA), which inhibits mRNA splicing. This system should serve to facilitate the discovery of novel compounds from natural resources that inhibit mRNA processing.

Citation

Ken-ichi Fujita, Masumi Okamura, Sachiko Nishimoto, Tomoya Kurihara, Keiko Momma, Yusaku Miyamae, Taiho Kambe, Masaya Nagao, Hiroshi Narita, Seiji Masuda. Establishment of a monitoring system to detect inhibition of mRNA processing. Bioscience, biotechnology, and biochemistry. 2012;76(6):1248-51