Identification of rat and human hemoglobin acetilation sites after its interaction with acetylsalicylic acid].

The possibility of interaction of 0.1 mg/mL acetylsalicylic acid with purified human and rat globin in vitro during 24 h at 37 degrees C was investigated. The rat globin can be modified with acetylsalicylic acid on aminoacid residues K-17, K-57, K-91, K-140 in alpha subunit as well as on K-18, K-77 in beta subunit. The human globin can be modified with acetylsalicylic acid on aminoacid residues K-17, K-41, K-57 and K-91 in alpha subunit as well as on K-18, K-96 and K- 133 in beta subunit. We identified of acetetylated lysines K-17 and K-57 in alpha subunit of human hemoglobin after incubation whole blood with 0.1 mg/mL acetylsalicylic acid during 3 h.

Citation

E V Shreĭner, E A Murashko, Ia D Dubrovskiĭ, N V Krasnov, E P Podol'skaia, V N Babakov. Identification of rat and human hemoglobin acetilation sites after its interaction with acetylsalicylic acid]. Bioorganicheskaia khimiia. 2012 Mar-Apr;38(2):149-55

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PMID: 22792718

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