Impact on absorption of berberine and palmatine in different compatibilities of Wuji pill].

Yiwei Wang, Yujie Li, Yanli Wang, Weipeng Yang, Ying Chen, Dong Zhang, Qing Yang, Yingfeng Zhang, Tao Li, Xiaoxin Zhu

China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, Beijing 100700, China.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 2012 Apr

filter terms:

To observe the impact on absorption of berberine and palmatine in different compatibilities of Wuji pill by the perfused rat intestine-liver preparation. Use L9 (3(4)) orthogonal design table, establish the perfused rat intestine-liver preparation, the twelve Wuji pill compatibilities duodenal administrated, collect the perfusate at different times points for LC-MS detection, calculate the absorbed score, Ka. Evodiae Fructus and the absorption score, Ka of berberine and palmatine are inverse correlated. The most superior portion which promote the absorption is Coptidis Rhizoma-Evodiae Fructus-Paeoniae Radix Alba 3:1:3. Evodiae Fructus suppressed the absorption of berberine and palmatine. With the different portion the absorption also have big different.

Citation

Yiwei Wang, Yujie Li, Yanli Wang, Weipeng Yang, Ying Chen, Dong Zhang, Qing Yang, Yingfeng Zhang, Tao Li, Xiaoxin Zhu. Impact on absorption of berberine and palmatine in different compatibilities of Wuji pill]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Apr;37(7):985-90