A new pathway for the repair of DNA alkylation damage is described in this issue of Molecular Cell (Latypov et al., 2012). Alkyltransferase-like enzymes mark O(6)-alkylguanine lesions and, depending on adduct size, channel them into global genome or transcription-coupled nucleotide excision repair pathways. Copyright © 2012 Elsevier Inc. All rights reserved.
Orlando D Schärer. Alkyltransferase-like proteins: brokers dealing with alkylated DNA bases. Molecular cell. 2012 Jul 13;47(1):3-4
PMID: 22793691
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