Water-soluble constituents of the heartwood of Streblus asper.

Jun Li, Mao-Tong Tang, Qiang Wu, Hong Chen, Xiao-Tao Niu, Xin-Lan Guan, Jian Li, Sheng-Ping Deng, Xiao-Jian Su, Rui-Yun Yang

Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Ministry of Education of China), School of Environment and Resource of Guangxi Normal University, Guilin 541004, PR China. lijun9593@mailbox.gxnu.edu.cn

Natural product communications 2012 May

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A new lignan, (7'R,8'R)-threo-strebluslignanol-2-O-beta-D-glucopyranoside, along with 8 known compounds (2-9) were isolated from the water-soluble part of the MeOH extract of the heartwood of Streblus asper. Their structures were elucidated through various spectroscopic methods, including 1D NMR (1H NMR, 13C NMR), 2D NMR (HMQC, HMBC, and NOESY), and HRMS. The stereochemistry at the chiral centers was determined using the CD spectrum, as well as analyses of coupling constants and optical rotation data. In the preliminary bioassay, the isolated compounds did not show anti-HBV activities in vitro using the HBV transfected HepG2.2.15 cell line.

Citation

Jun Li, Mao-Tong Tang, Qiang Wu, Hong Chen, Xiao-Tao Niu, Xin-Lan Guan, Jian Li, Sheng-Ping Deng, Xiao-Jian Su, Rui-Yun Yang. Water-soluble constituents of the heartwood of Streblus asper. Natural product communications. 2012 May;7(5):599-602