Effects of Prolyl-Glycyl-Proline (PGP) peptide on disorders in rat mesenteric lymphatic vessel function induced by injection of substance 48/80.

B A Umarova, N S Bondarenko, T V Lelekova, G N Kopylova, G E Samonina

Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Russia. bellaum@mail.ru

Bulletin of experimental biology and medicine 2012 Feb

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Injection of substance 48/80 to rats led to dysfunction of mesenteric lymphatic microvessels, in particular inhibition of their contractility and modification of their reaction to norepinephrine. Injection of PGP peptide before and after substance 48/80 alleviated these disorders. The results indicated the possibility of peptide correction of lymphatic vessel dysfunction.

Citation

B A Umarova, N S Bondarenko, T V Lelekova, G N Kopylova, G E Samonina. Effects of Prolyl-Glycyl-Proline (PGP) peptide on disorders in rat mesenteric lymphatic vessel function induced by injection of substance 48/80. Bulletin of experimental biology and medicine. 2012 Feb;152(4):447-50