Villarinol, a new alkenoyloxyalkenol derivative from the endemic Philippine Rubiaceae species Villaria odorata.

Allan Patrick G Macabeo, Jalil A Avila, Grecebio Jonathan D Alejandro, Scott G Franzblau, Simeon F Kouam, Hidayat Hussain, Karsten Krohn

Phytochemistry and Organic Synthesis Laboratory, Research Center for the Natural and Applied Sciences, University of Santo Tomas, Espana, Manila 1015, Philippines. allanpatrick_m@yahoo.com

Natural product communications 2012 Jun

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Villarinol (1), a new alkenoyloxy alkenol metabolite, has been isolated from the dichloromethane extract of Villaria odorata, an endemic Rubiaceae Philippine plant, along with the known compounds stigmasterol and 4-hydroxybenzaldehyde. The structure of 1 was elucidated on the basis of spectroscopic and spectrometric studies. The extracts of V. odorata exhibited moderate inhibition against Mycobacterium tuberculosis H37Rv, based on the colorimetric microplate alamar blue assay.

Citation

Allan Patrick G Macabeo, Jalil A Avila, Grecebio Jonathan D Alejandro, Scott G Franzblau, Simeon F Kouam, Hidayat Hussain, Karsten Krohn. Villarinol, a new alkenoyloxyalkenol derivative from the endemic Philippine Rubiaceae species Villaria odorata. Natural product communications. 2012 Jun;7(6):779-80