Senior-Løken syndrome: a syndromic form of retinal dystrophy associated with nephronophthisis.

C C Ronquillo, P S Bernstein, W Baehr

Vision research 2012 Dec 15

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Senior-Løken syndrome (SLS) is an autosomal recessive disease characterized by development of a retinitis pigmentosa (RP)- or Leber congenital amaurosis (LCA)-like retinal dystrophy and a medullary cystic kidney disease, nephronophthisis. Mutations in several genes (called nephrocystins) have been shown to cause SLS. The proteins encoded by these genes are localized in the connecting cilium of photoreceptor cells and in the primary cilium of kidney cells. Nephrocystins are thought to have a role in regulating transport of proteins bound to the outer segment/primary cilium; however, the precise molecular mechanisms are largely undetermined. This review will survey the biochemistry, cell biology and existing animal models for each of the nephrocystins as it relates to photoreceptor biology and pathogenesis of retinal degeneration. Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

C C Ronquillo, P S Bernstein, W Baehr. Senior-Løken syndrome: a syndromic form of retinal dystrophy associated with nephronophthisis. Vision research. 2012 Dec 15;75:88-97