Bioactive aldehyde-modified phosphatidylethanolamines.

Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University, Nashville, TN 37232-6602, USA. lilu.guo@vanderbilt.edu

Biochimie 2013 Jan

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Lipid peroxidation generates a variety of lipid aldehydes, which have been recognized to modify protein and DNA, causing inflammation and cancer. However, recent studies demonstrate that phosphatidylethanolamine (PE) is a major target for these aldehydes, forming aldehyde-modified PEs (al-PEs) as a novel family of mediators for inflammation. This review summarizes our current understanding of these al-PEs, including formation, detection, structural characterization, physiological relevance and mechanism of action. Copyright © 2012 Elsevier Masson SAS. All rights reserved.