Positive C1q staining associated with poor renal outcome in membranoproliferative glomerulonephritis.

Pathogenesis and clinical prognosis of membranoproliferative glomerulonephritis (MPGN) has not yet been established. We conducted a retrospective study of 41 patients with MPGN (type I and III) and examined the renal survival. In addition, factors contributing to survival time were analyzed. Fourteen patients (34 %) were classified into the renal death group. Patients with nephrotic syndrome and positive C1q staining of glomerular deposits showed a particularly poor prognosis. Significantly higher frequency of nephrotic syndrome and higher urinary protein excretion were observed in the renal death group (p = 0.0002, p = 0.0002) than in the renal survival group. The intensity of C1q staining was positively correlated with the severity of the proteinuria (p = 0.004). Factors that influenced the survival time were positive C1q staining of glomerular deposits (p = 0.003), presence of nephrotic syndrome (p = 0.004), serum albumin (p = 0.02), and proteinuria (p = 0.04). C1q staining in glomerular deposits and nephrotic syndrome were important factors influencing the prognosis and outcome in MPGN patients. C1q deposition may play a key role in the pathogenesis of MPGN, as evidenced by numerous observations, such as induction of proteinuria.

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Takashi Takei, Mitsuyo Itabashi, Takahito Moriyama, Ari Shimizu, Yuki Tsuruta, Ayami Ochi, Kayu Nakayama, Chihiro Iwasaki, Keiko Uchida, Kosaku Nitta. Positive C1q staining associated with poor renal outcome in membranoproliferative glomerulonephritis. Clinical and experimental nephrology. 2013 Feb;17(1):92-8

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PMID: 22821391

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