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The aim of this work was to study, by immunoprecipitation, in situ hybridization and immunohistochemistry, and the expression of the vasoactive intestinal peptide (VIP) and of its receptors (VPAC(1)R and VPAC(2)R) in the testis of a nonmammalian vertebrate, the cartilaginous fish Torpedo marmorata. We demonstrated that, differently from mammals, VIP and VPAC(2)R were widely distributed in the testicular cells while the VPAC(1)R had a limited distribution. In details, we showed that VIP and VPAC(2)R were present in mitotic and differentiating germ cells as well as in the cells involved in the steroidogenesis, i.e., Leydig, Sertoli cells, and prespermatogonia and spermatogonia. The possibility that VIP is involved in the spermatogenesis and particularly in the steroidogenesis of T. marmorata is discussed.


Marisa Agnese, Luigi Rosati, Francesco Muriano, Salvatore Valiante, Vincenza Laforgia, Piero Andreuccetti, Marina Prisco. Expression of VIP and its receptors in the testis of the spotted ray Torpedo marmorata (Risso 1880). Journal of molecular neuroscience : MN. 2012 Nov;48(3):638-46

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PMID: 22825651

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