The effect of food on the oral bioavailability of drugs: a review of current developments and pharmaceutical technologies for pharmacokinetic control.

Takehiko Yasuji, Hiromu Kondo, Kazuhiro Sako

Pharmaceutical Research & Technology Labs. Astellas Pharma Inc., 180 Ozumi, Yaizu. Shizuoka 425-0072, Japan.

Therapeutic delivery 2012 Jan

filter terms:

Here we review the mediation of the food effects on drugs by pharmaceutical technologies. The pharmacokinetics of drugs are affected by the interaction of drugs with food, which changes drug physicochemical and physiological properties (food effects). Several pharmaceutical technologies may be used to control food effects. Drugs exhibit different patterns of solubilization depending on release formulations. Formulations such as nanoparticle, solid dispersion and cyclodextrin systems, may control the solubility and release of insoluble drugs. Other controlled-release technologies, such as osmotic-controlled release or colon-specific delivery systems may also control food effects. As the structure of drug candidates becomes more complex, different methods of investigation, such as in vitro and in vivo correlation and in silico simulation will be required to predict drug characteristics and food effects.

Citation

Takehiko Yasuji, Hiromu Kondo, Kazuhiro Sako. The effect of food on the oral bioavailability of drugs: a review of current developments and pharmaceutical technologies for pharmacokinetic control. Therapeutic delivery. 2012 Jan;3(1):81-90