Effects of mexidol and sulodexide on the level of specific markers of endothelial dysfunction in animals with experimental diabetes mellitus].

I N Tiurenkov, A V Voronkov, A A Slietsans, G L Snigur

Eksperimental'naia i klinicheskaia farmakologiia 2012

filter terms:

Streptozotocin-induced diabetes leads to the development of endothelial dysfunction, as evidenced by decreased expression of endothelial nitric oxide synthase (eNOS) and increased expression of endothelin-1 as specific markers of endothelial disorders. All test substances showed endotelioprotective activity by increasing the concentration of eNOS and reducing the level of endothelin-1. With respect to the degree of impact on the eNOS and endothelin-1 levels, the compounds studied can be rated as follows: sulodexide > meksidol.

Citation

I N Tiurenkov, A V Voronkov, A A Slietsans, G L Snigur. Effects of mexidol and sulodexide on the level of specific markers of endothelial dysfunction in animals with experimental diabetes mellitus]. Eksperimental'naia i klinicheskaia farmakologiia. 2012;75(5):14-6