The role of serotonin in the immune system development and functioning during ontogenesis].

V I Mel'nikova, M S Izvol'skaia, S N Voronova, L A Zakharova

Izvestiia Akademii nauk. Seriia biologicheskaia / Rossiĭskaia akademiia nauk 2012 May-Jun

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In this study, we investigated the influence of serotonin on the development and functioning of T- and B-cell-mediated immunity during ontogenesis using the pharmacological model of serotonin depletion in rat fetuses. It has been demonstrated that prenatal serotonin deficiency resulted in a decrease in thymus and spleen weights, changes in their cellular composition, and long-lasting disturbances in cell-mediated and humoral immunity in postnatal ontogenesis. The data obtained suggest that serotonin may be considered a morphogenic factor in development of the immune system.

Citation

V I Mel'nikova, M S Izvol'skaia, S N Voronova, L A Zakharova. The role of serotonin in the immune system development and functioning during ontogenesis]. Izvestiia Akademii nauk. Seriia biologicheskaia / Rossiĭskaia akademiia nauk. 2012 May-Jun(3):288-95