Chikungunya virus nsP3 blocks stress granule assembly by recruitment of G3BP into cytoplasmic foci.

Jelke J Fros, Natalia E Domeradzka, Jim Baggen, Corinne Geertsema, Jacky Flipse, Just M Vlak, Gorben P Pijlman

Journal of virology 2012 Oct

filter terms:

Chikungunya virus nonstructural protein nsP3 has an essential but unknown role in alphavirus replication and interacts with Ras-GAP SH3 domain-binding protein (G3BP). Here we describe the first known function of nsP3, to inhibit stress granule assembly by recruiting G3BP into cytoplasmic foci. A conserved SH3 domain-binding motif in nsP3 is essential for both nsP3-G3BP interactions and viral RNA replication. This study reveals a novel role for nsP3 as a regulator of the cellular stress response.

Citation

Jelke J Fros, Natalia E Domeradzka, Jim Baggen, Corinne Geertsema, Jacky Flipse, Just M Vlak, Gorben P Pijlman. Chikungunya virus nsP3 blocks stress granule assembly by recruitment of G3BP into cytoplasmic foci. Journal of virology. 2012 Oct;86(19):10873-9