A study of the inclusion complex of WB852 with beta-cyclodextrin].

S L Wang, D S Su, Z Z Ji

Shenyang College of Pharmacy.

Yao xue xue bao = Acta pharmaceutica Sinica 1990

filter terms:

The aim of this study was to increase the stability of WB852 in aqueous solution by inclusion complex formation with beta-cyclodextrin (beta-CD). The stability of WB852-beta-CD in aqueous solution was determined. The hydrolysis rate of WB852 from the inclusion compound was lower than that of WB852 alone. The solid inclusion compound of WB852 with beta-CD in 1:3 molar ratio was prepared by the freeze-drying method. The formation of an inclusion compound with beta-CD in solid state was confirmed by X-ray diffractometry, IR spectroscopy and differential thermal analysis (DTA).

Citation

S L Wang, D S Su, Z Z Ji. A study of the inclusion complex of WB852 with beta-cyclodextrin]. Yao xue xue bao = Acta pharmaceutica Sinica. 1990;25(6):477-80