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Although aminoacyl tRNA synthetases (aaRSs) act in translation, numerous examples demonstrate ex-translational functions in fundamental networks of higher organisms. These functions involve modified versions of aaRSs and natural fragments. The interplay of aaRS-derived entities appears to be at the heart of homeostatic mechanisms controlling angiogenesis, inflammation, metabolism, and tumorigenesis. Copyright © 2012 Elsevier Ltd. All rights reserved.


Min Guo, Paul Schimmel. Homeostatic mechanisms by alternative forms of tRNA synthetases. Trends in biochemical sciences. 2012 Oct;37(10):401-3

PMID: 22858252

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