Tripeptide Pro-Gly-Pro prevents disturbances in osmotic resistance of rat erythrocytes under conditions of inflammation.

M G Golubeva, B A Umarova, G N Kopylova, G E Samonina, N S Bondarenko, O V Cheremnova

Department of Human and Animal Physiology, MV Lomonosov Moscow State University, Russia. mgolubeva46@mail.ru

Bulletin of experimental biology and medicine 2012 Jul

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The development of inflammation (experimental model of peritonitis induced by administration of sodium thioglycolate) was accompanied by a decrease in osmotic resistance of erythrocytes. Changes in osmotic resistance of erythrocytes associated with preliminary (15 min before induction of inflammation) administration of peptide Pro-Gly-Pro were significantly weaker, and the percentage of hemolyzed cells was reduced. The peptide injected against the background of developed inflammation (1 h 45 min after induction) had no corrective effect on osmotic resistance. During in vitro experiments, Pro-Gly-Pro did not affect hemolysis of intact erythrocytes. These results support the assumption that prophylactic administration of the peptide protects erythrocyte membranes and increases their osmotic resistance.

Citation

M G Golubeva, B A Umarova, G N Kopylova, G E Samonina, N S Bondarenko, O V Cheremnova. Tripeptide Pro-Gly-Pro prevents disturbances in osmotic resistance of rat erythrocytes under conditions of inflammation. Bulletin of experimental biology and medicine. 2012 Jul;153(3):295-7