Directing reprogramming to pluripotency by transcription factors.

Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, Germany.

Current opinion in genetics & development 2012 Oct

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The pluripotent state is governed by specifically expressed transcription factors forming a highly interconnected regulatory network in concert with more widely expressed transcription factors. The transcriptional network exhibits a hierarchical structure, with a small number of transcription factors playing an essential role in maintaining pluripotency and controlling the more numerous auxiliary transcription factors. When the set of master transcription factors comprising Oct4, Sox2, Klf4, and Myc is expressed ectopically in somatic cells, the transcriptional network is propelled to organize itself in such a way as to support a pluripotent state. These transcription factors play distinct but interdependent roles in remodeling gene expression by influencing the local chromatin status during reprogramming. Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

Kenjiro Adachi, Hans R Schöler. Directing reprogramming to pluripotency by transcription factors. Current opinion in genetics & development. 2012 Oct;22(5):416-22