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Raloxifene is an anti-resorptive agent used in postmenopausal osteoporosis. This is the first report of the occurrence of clinically significant hypocalcemia following raloxifene treatment in a patient with occult vitamin D deficiency. Since vitamin D deficiency is widely prevalent in the community, screening for vitamin D deficiency and its correction is advisable before the initiation of anti-resorptive therapy.


Thuy D T Vu, Suresh Varadarajan, Ego Seeman, George Jerums, Richard J MacIsaac. Hypocalcemia induced by raloxifene. Current drug safety. 2012 Apr;7(2):176-8

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PMID: 22873502

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