A rare cause of childhood-onset nephrotic syndrome: lipoprotein glomerulopathy.

Min-Tser Liao, I-Jung Tsai, Hui-Teng Cheng, Wei-Chou Lin, Yen-Wen Chang, Yi-Heng Lin, Yong-Kwei Tsau

Department of Pediatrics, Taoyuan Armed Forces General Hospital, Taiwan.

Clinical nephrology 2012 Sep

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We report on a 12-year-old female patient with lipoprotein glomerulopathy (LPG) who was proven to be heterozygous for ApoE2 Kyoto (Arg25Cys). Her family members have the same variant but do not have obvious signs of renal function impairment. Six months of treatment with a statin caused significant clinical improvement in the lipid profile, proteinuria, and renal function. Our case suggests that administration of a statin is a potential therapeutic strategy for improving nephrotic syndrome in patients with LPG.

Citation

Min-Tser Liao, I-Jung Tsai, Hui-Teng Cheng, Wei-Chou Lin, Yen-Wen Chang, Yi-Heng Lin, Yong-Kwei Tsau. A rare cause of childhood-onset nephrotic syndrome: lipoprotein glomerulopathy. Clinical nephrology. 2012 Sep;78(3):237-40