Endocytic receptors in the renal proximal tubule.

Erik I Christensen, Henrik Birn, Tina Storm, Kathrin Weyer, Rikke Nielsen

Department of Biomedicine, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark. eic@ana.au.dk

Physiology (Bethesda, Md.) 2012 Aug

filter terms:

Protein reabsorption is a predominant feature of the renal proximal tubule. Animal studies show that the ability to rescue plasma proteins relies on the endocytic receptors megalin and cubilin. Recently, studies of patients with syndromes caused by dysfunctional receptors have supported the importance of these for protein clearance of human ultrafiltrate. This review focuses on the molecular biology and physiology of the receptors and their involvement in renal pathological conditions.

Citation

Erik I Christensen, Henrik Birn, Tina Storm, Kathrin Weyer, Rikke Nielsen. Endocytic receptors in the renal proximal tubule. Physiology (Bethesda, Md.). 2012 Aug;27(4):223-36