Heavy binge drinking may increase risk of stroke in nonalcoholic hypertensives carrying variant ALDH2*2 gene allele.

Ching-Long Lai, Meng-Ta Liu, Shih-Jiun Yin, Jiunn-Tay Lee, Chun-Chung Lu, Giia-Sheun Peng

Department of Nursing, Chang Gung University of Science and Technology, Taoyuan.

Acta neurologica Taiwanica 2012 Mar

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Epidemiologic evidence demonstrates that heavy drinking increases the risk of stroke. However, whether recent heavy drinking affects the incidence of acute stroke in nonalcoholic individuals with the variant allele ALDH2*2 has not been reported. Two previously nonalcoholic healthy men suffered from acute ischemic stroke after a single episode of binge drinking. Both patients had one risk factor for stroke (a history of hypertension) and were heterozygous for ALDH2*2. CONCULUSION: The confluence of these factors with stroke has raised the possibility that heavy binge drinking increases the risk of acute stroke in hypertensives with the variant ALDH2*2 gene allele.

Citation

Ching-Long Lai, Meng-Ta Liu, Shih-Jiun Yin, Jiunn-Tay Lee, Chun-Chung Lu, Giia-Sheun Peng. Heavy binge drinking may increase risk of stroke in nonalcoholic hypertensives carrying variant ALDH2*2 gene allele. Acta neurologica Taiwanica. 2012 Mar;21(1):39-43